Director/PDMR Share Dealings

Director/PDMR Share Dealings January 2, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat on January 1, 2015, Flemming Ornskov and Phil Vickers, Persons DischargingManagerial Responsibilities, were granted options over American DepositaryShares ("ADSs") pursuant to the Shire Employee Stock Purchase Plan. Both haveelected to save US$568.18 per fortnight. The option price will be the lower of85% of the fair market value of an ADS on December 31, 2014, and 85% of thefair market value of an ADS on the exercise date, October 31, 2015. One ADS isequal to three ordinary shares of 5 pence each in the Company. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor Relations Jeff Poulton [email protected] +1 781 482 0945 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com