Director/PDMR Share Dealings

Director/PDMR Share Dealings October 27, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesit was notified today that Susan Kilsby, Chairman of the Company, acquired2,500 American Depositary Shares ("ADSs") on October 24, 2014 at an averageprice of US$194.4264 per ADS. Following the above transaction, Ms Kilsby holds 3,041 ADSs. One ADS is equalto three ordinary shares of 5 pence each in the Company. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor RelationsJeff Poulton [email protected] +1 781 482 0945Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com