Director/PDMR Share Dealings

Press Release www.shire.com Director/PDMR Share Dealings February 3, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat it was notified today that deferred American Depositary Shares ("ADSs")granted to Ginger Gregory, a Person Discharging Managerial Responsibilities,were automatically released today in accordance with the terms of a DeferredShare Award granted in February 2014. One ADS is equal to three Ordinary sharesof 5 pence each in the Company. The number of ADSs released and the number that lapsed are as follows: ADSs Released(1) ADSs Lapsed(2) 2,901 1,831 1. In accordance with the terms of the Deferred Share Award, the vested deferred ADSs were increased by an amount equivalent, at the date of vesting, to the value of dividends paid by the Company from the date of grant to the date of vesting. 2. The number of ADSs lapsed is equivalent in value to Ms. Gregory's tax liability resulting from the release of the deferred ADSs. 3. No amount was payable by Ms. Gregory on release. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor RelationsSarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com

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