Director’s Share Dealings

Director's Share Dealings February 21, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")announces it was notified on February 20, 2014 that on that day, MatthewEmmens, the Company's Chairman, sold 36,100 Ordinary Shares in the Company("Shares") at an average sale price of £33.14853. The Shares were sold on theLondon Stock Exchange. Following the above transaction, Mr Emmens holds 56,774 Shares and 5,872American Depositary Shares in the Company ("ADSs"). Each ADS represents threeShares. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Laurie Stelzer [email protected] +1 858 754 5480 Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal andInternal Medicine and we are developing treatments for symptomatic conditionstreated by specialist physicians in other targeted therapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com