Director’s Share Dealings

Director's Share Dealings February 17, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces it wasnotified today that on February 14, 2014, Graham Hetherington, Chief FinancialOfficer, exercised a Stock Appreciation Right Award ("Award"). The Award wasgranted in 2010 under the Shire Portfolio Share Plan over Shire plc ordinaryshares of 5p each ("Shares"). Number of Exercise Number of Average price Shares received sale price Shares and sold exercised 134,814 £14.43 72,821 £31.46747 The Shares were sold on the London Stock Exchange on February 14, 2014. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal andInternal Medicine and we are developing treatments for symptomatic conditionstreated by specialist physicians in other targeted therapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com