Director’s Share Dealing

Director's Share Dealing February 20, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")announces it was notified today that on February 19, 2014, Graham Hetherington,the Company's Chief Financial Officer, sold 40,000 Ordinary Shares in theCompany ("Shares") at an average sale price of £33.34251. The Shares were soldon the London Stock Exchange. Following the above transaction, Mr Hetherington holds 52,089 Shares. This notification is to satisfy the Company's obligations under 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal andInternal Medicine and we are developing treatments for symptomatic conditionstreated by specialist physicians in other targeted therapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com