Director Shareholding

27 December 2013

Healthcare Investment Opportunities Plc

(the "Company")

Director Shareholding

Healthcare Investment Opportunities plc (AIM: HIO), an investment company focusing on the healthcare sector, announces that today Malcolm Gillies, a Director of Healthcare Investment Opportunities, has purchased a total of 250,000 ordinary shares at an average price of 12.789 pence per share.

This brings Malcolm Gillies' interest in the Company's current issued share capital to 500,000 being 1.24% of the current issued share capital.

Enquiries:

Healthcare Investment Opportunities Plc

David Evans, Chairman Tel: 07740 084 452

Zeus Capital (Nominated Adviser and Broker)

Ross Andrews / John Depasquale (Corporate Finance) Tel: 0161 831 1512

Dominic Wilson (Institutional Sales) Tel: 020 7533 7727

Walbrook PR Ltd Tel: 020 7933 8780 or [email protected]

Mike Wort Mob: 07900 608 002