Director Share Dealings

Director Share Dealings September 30, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")announces that today Ordinary Shares ("Shares") and American Depository Shares("ADSs") of the Company, as set out below, have been acquired for theNon-Executive Directors, being the part of their total fees that are paid inshares for the period of service from July 1 to September 30, 2014. Type of Security(1) Number of Shares/ADSs Dominic Blakemore Shares 98 William Burns Shares 99 Dr. Steven Gillis ADSs 32 Dr. David Ginsburg ADSs 30 David Kappler Shares 104 Susan Kilsby ADSs 100 Anne Minto Shares 104 David Stout ADSs 32 (1) One ADS is equal to three Shares The Shares and ADSs were acquired on the London Stock Exchange and NASDAQrespectively at prices of £53.45 per Share and $259.9747 per ADS. This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)of the Disclosure and Transparency Rules. Tony GuthrieDeputy Company Secretary For further information please contact: Investor RelationsJeff Poulton [email protected] +1 781 482 0945Sarah Elton-Farr [email protected] +44 1256 894157 MediaStephanie Fagan [email protected] +1 781 482 0460Gwen Fisher [email protected] +1 484 595 9836 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com