Director Declaration

SHIRE PLC - Director Declaration

PR Newswire

London, January 4

Director Declaration

January 4, 2017 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”) announces that Ian Clark, Non-Executive Director of the Company, was appointed to the Boards of Directors of Agios Pharmaceuticals, Inc. and Corvus Pharmaceuticals, Inc. on January 3, 2017.

This notification is to satisfy the Company’s obligations under LR 9.6.14R of the UK Listing Rules.

Oliver StrawbridgeSenior Assistant Company Secretary

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NOTES TO EDITORS

About Shire

Shire is the leading global biotechnology company focused on serving people with rare diseases and other highly specialized conditions. We strive to develop best-in-class products, many of which are available in more than 100 countries, across core therapeutic areas including Hematology, Immunology, Neuroscience, Ophthalmics, Lysosomal Storage Disorders, Gastrointestinal / Internal Medicine / Endocrine and Hereditary Angioedema; and a growing franchise in Oncology.

Our employees come to work every day with a shared mission: to develop and deliver breakthrough therapies for the hundreds of millions of people in the world affected by rare diseases and other high-need conditions, and who lack effective therapies to live their lives to the fullest.

www.shire.com