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Director Declaration

4th May 2011 15:14

Director Declaration

May 4, 2011 - Shire plc , the global specialty biopharmaceutical company announces that, in accordance with Listing Rule LR 9.6.14, its non-executive director, William Burns, has joined the board of Biotie Therapies Corp., with effect from February 1, 2011.

Tony GuthrieDeputy Secretary

For further information please contact:

Investor Eric Rojas [email protected] +1 781 482 0999 Relations Sarah Elton-Farr [email protected] +44 1256 894157

Notes to editors

SHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company's website: www.shire.com.

2Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PXPress Release

www.shire.com

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