Director Declaration

Director Declaration March 4, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat its Non-Executive Director, David Kappler, was appointed as aNon-Executive Director of Flybe Group plc with effect from March 3, 2015. This notification is to satisfy the Company's obligations under 9.6.14R of theUK Listing Rules. Tony Guthrie Deputy Company Secretary For further information please contact: Investor Relations Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com