Co-Founder and NED Prof Chris McGuigan Passes Away

www.tizianalifesciences.com | AIM: TILS

Tiziana Life Sciences PLC ("Tiziana" or the "Company")

Tiziana Life Sciences Co-Founder and Non-Executive Director Professor Chris McGuigan Passes Away

London, 15 March 2016 - Tiziana Life Sciences plc (AIM: TILS, the "Company"), a clinical stage biotechnology company focused on targeted drugs to treat diseases in oncology and immunology, notes the passing of Professor Chris McGuigan on Friday 11 March 2016. Prof. McGuigan was a co-founder of Tiziana Life Sciences and was appointed as a Non-executive Director in January 2015.

Gabriele Cerrone, Chairman of Tiziana, said: "I was deeply saddened to learn of the passing of Professor Chris McGuigan. As well as being a close personal friend, Chris and I also collaborated together on several successful biotech ventures. The Board and I will miss his wise counsel and we send our heart-felt condolences to his family at this difficult time."

About Tiziana Life Sciences

Tiziana Life Sciences plc is a UK biotechnology company that focuses on the discovery and development of novel molecules that treat human disease in oncology and immunology.

The Company is focused on its lead compound, milciclib, a molecule which blocks the action of specific enzymes called cyclin-dependent kinases (CDK) involved in cell division as well as a number of other protein kinases. Milciclib is currently in phase II clinical trials for thymic carcinoma in patients previously treated with chemotherapy.

The Company is also in clinical development of foralumab. Foralumab is the only fully human engineered anti-human CD3 antibody in clinical development. This phase II compound has potential application in a wide range of autoimmune and inflammatory diseases, such as ulcerative colitis, multiple sclerosis, type-1 diabetes (T1D), inflammatory bowel disease (IBD), psoriasis and rheumatoid arthritis, where modulation of a T-cell response is desirable.

Tiziana Life Sciences' clinical development teams are working on its Bcl-3 candidate; which has a prominent role in the metastasis of mammary cancers, and has elucidated the mechanism of Bcl-3 action to be a regulator of cancer cell motility and has also determined that Bcl-3 inhibition suppresses cell motility in triple-negative, HER-2-positive PR- and ER-positive breast cancer sub-types, suggesting that Bcl-3 may be a master regulator of this metastatic property not only in aggressive breast cancers, but across the clinical spectrum of breast disease. The Company is preparing the IND package with the intention of progressing to clinical trials this year.

For more information go to http://www.tizianalifesciences.com

Forward-Looking Statements

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Source: Tiziana Life Sciences