Changes to membership of Board Committees

Changes to Board Committees of AstraZeneca PLC ("AstraZeneca")

AstraZeneca announced today that Graham Chipchase, Non-Executive Director, has been appointed as a member of the Remuneration Committee with immediate effect. At the same time, Mr Chipchase has stepped down from the Audit Committee.

AstraZeneca also confirmed that, as previously indicated, Ann Cairns became a member of the Audit Committee upon her election to the Board on 24 April 2014.

The compositions of the Audit Committee and Remuneration Committee are now:

Audit Committee: Rudy Markham (Chairman), Bruce Burlington, Ann Cairns, Jean-Philippe Courtois, Shriti Vadera.

Remuneration Committee: John Varley (Chairman), Leif Johansson, Rudy Markham, Nancy Rothwell, Graham Chipchase.

This announcement is made pursuant to Listing Rule 9.6.11.

A C N Kemp

Company Secretary

6 May 2014