Change of Adviser

FINAL DRAFT

9 March 2010

Epistem Holdings Plc ("Epistem")

Change of Nominated Adviser and Broker

Epistem (LSE: EHP), the rapidly growing UK biotechnology company with adult epithelial stem cell expertise in oncology, gastrointestinal and dermatological diseases today announces the appointment of KBC Peel Hunt Ltd as its nominated adviser and broker with immediate effect.

For further information, please contact:

Epistem Plc

Matthew Walls Chief Executive Officer 07887 501998

John Rylands Finance Director 0161 606 7244

KBC Peel Hunt Ltd

James Steel Qualified Executive 020 7418 8900

Vijay Barathan 020 7418 8900

De Facto Communications

Mike Wort / Anna Dunphy 020 7861 3838