Cancellation of listing of Shire Convertible Bonds

Cancellation of listing and admission to trading of Shire plcU.S.$1,100,000,000 2.75 per cent. Convertible Bonds due 2014 with ISIN:XS0299687482 (the "Bonds") January 17, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") announcesthat, further to the receipt by the Company of bondholder conversion notices inrespect of Bonds in the aggregate principal amount of U.S.$1,099,050,000, theredemption of Bonds in the aggregate principal amount of U.S.$950,000 and theannouncement made by the Company on December 16, 2013, the listing of the Bondson the Official List of the UK Listing Authority and the admission of the Bondsto trading on the Professional Securities Market of the London Stock Exchangeis hereby cancelled with effect from the date of this announcement. For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal andInternal Medicine and we are developing treatments for symptomatic conditionstreated by specialist physicians in other targeted therapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com