26th May 2006 09:11
BLOCK LISTING SIX MONTHLY RETURN Basingstoke, UK and Philadelphia, US - May 26, 2006 - Shire plc (LSE: SHP,NASDAQ: SHPGY, TSX: SHQ)Name of applicant: SHIRE PLC Name of scheme: STOCK PURCHASE PLAN Period of return: From: 26 November To: 25 May 2006 2005 Balance under scheme from previous Nil return: The amount by which the block scheme Nil has been increased, if the scheme has been increased since the date of the last return: Number of securities issued/allotted 223,621 under scheme during period: Balance under scheme not yet issued/ 1,776,379 allotted at end of period Number and class of securities 2,000,000 on 25 November 2005 originally listed and the date of admission Total number of securities in issue at 498,833,835 the end of the period Name of applicant: SHIRE PLC Name of scheme: 1996 EXECUTIVE SHARE OPTION SCHEME Period of return: From: 26 November To: 25 May 2006 2005 Balance under scheme from previous Nil return: The amount by which the block scheme Nil has been increased, if the scheme has been increased since the date of the last return: Number of securities issued/allotted 198,826 under scheme during period: Balance under scheme not yet issued/ 1,001,174 allotted at end of period Number and class of securities 1,200,000 on 25 November 2005 originally listed and the date of admission Total number of securities in issue at 498,833,835 the end of the period Name of applicant: SHIRE PLC Name of scheme: 2000 EXECUTIVE SHARE OPTION SCHEME Period of return: From: 26 November To: 25 May 2006 2005 Balance under scheme from previous Nil return: The amount by which the block scheme Nil has been increased, if the scheme has been increased since the date of the last return: Number of securities issued/allotted 2,116,076 under scheme during period: Balance under scheme not yet issued/ 7,883,924 allotted at end of period Number and class of securities 10,000,000 on 25 November 2005 originally listed and the date of admission Total number of securities in issue at 498,833,835 the end of the period Name of applicant: SHIRE PLC Name of scheme: SHIRE PLC SHARESAVE SCHEME Period of return: From: 26 November To: 25 May 2006 2005 Balance under scheme from previous Nil return: The amount by which the block scheme Nil has been increased, if the scheme has been increased since the date of the last return: Number of securities issued/allotted 47,662 under scheme during period: Balance under scheme not yet issued/ 952,338 allotted at end of period Number and class of securities 1,000,000 on 25 November 2005 originally listed and the date of admission Total number of securities in issue at 498,833,835 the end of the period Name of applicant: SHIRE PLC Name of scheme: BIOCHEM PHARMA STOCK OPTION PLAN Period of return: From: 26 November To: 25 May 2006 2005 Balance under scheme from previous Nil return: The amount by which the block scheme Nil has been increased, if the scheme has been increased since the date of the last return: Number of securities issued/allotted 10,930 under scheme during period: Balance under scheme not yet issued/ 3,589,070 allotted at end of period Number and class of securities 3,600,000 on 25 November 2005 originally listed and the date of admission Total number of securities in issue at 498,833,835 the end of the period Name of applicant: SHIRE PLC Name of scheme: EXCHANGEABLE SHARES IN SHIRE ACQUISITION INC Period of return: From: 2 February 2006 To: 25 May 2006 Balance under scheme from previous Nil return: The amount by which the block scheme Nil has been increased, if the scheme has been increased since the date of the last return: Number of securities issued/allotted 195,900 under scheme during period: Balance under scheme not yet issued/ 2,804,100 allotted at end of period Number and class of securities 3,000,000 on 2 February 2006 originally listed and the date of admission Total number of securities in issue at 498,833,835 the end of the period Name of contact: Vivienne Hemming - Deputy Company Secretary Address of contact: Shire plc, Lime Tree Way, Hampshire International Business Park, Chinham, Basingstoke, RG24 8EP Telephone number of contact: +44 1256 894 276 For further information please contact:Investor Relations Clĩa Rosenfeld (Rest of the World) +44 1256 894 160 Brian Piper (North America) +1 484 595 8252 Notes to editorsSHIRE PLCShire's strategic goal is to become the leading specialty pharmaceuticalcompany that focuses on meeting the needs of the specialist physician. Shirefocuses its business on central nervous system, gastrointestinal, generalproducts and human genetic therapies. The structure is sufficiently flexible toallow Shire to target new therapeutic areas to the extent opportunities arisethrough acquisitions. Shire believes that a carefully selected portfolio ofproducts with a strategically aligned and relatively small-scale sales forcewill deliver strong results.Shire's focused strategy is to develop and market products for specialtyphysicians. Shire's in-licensing, merger and acquisition efforts are focused onproducts in niche markets with strong intellectual property protection eitherin the US or Europe.For further information on Shire, please visit the Company's website: www.shire.com. Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release Registered in England05492592Registered Office as aboveENDSHIRE PLCRelated Shares:
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