Block Listing Six Monthly Return

BLOCK LISTING SIX MONTHLY RETURN

May 23, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG)

Name of applicant: Shire plc Name of scheme: 2000 Executive Share Option Scheme Period of return: From: November 23, To: May 22, 2013 2012 Balance of unallotted securities under 3,476,451scheme(s) from previous return: Plus: The amount by which the block Nilscheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ 29,569allotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 3,446,882yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: November 23, To: May 22, 2013 2012 Balance of unallotted securities under 115,392scheme(s) from previous return: Plus: The amount by which the block 95,000scheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ Nilallotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 210,392yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Portfolio Share Plan Period of return: From: November 23, To: May 22, 2013 2012 Balance of unallotted securities under 2,664,097scheme(s) from previous return: Plus: The amount by which the block Nilscheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ 263,117allotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 2,400,980yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Employee Stock Purchase Plan Period of return: From: March 6, 2013 To: May 22, 2013 Balance of unallotted securities under Nilscheme(s) from previous return: Plus: The amount by which the block 90,000scheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ Nilallotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 90,000yet issued/allotted at end of period: Name of contact: Tony Guthrie, Deputy Company Secretary Address of contact: Hampshire International Business Park Basingstoke, Hampshire, RG24 8EP Telephone number of contact: 01256 894746

For further information please contact:

Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas.

www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release

www.shire.com