Block Listing Six Monthly Return

Block Listing Six Monthly Return November 25, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) Name of applicant: Shire plc Name of scheme: 2000 Executive Share Option Scheme Period of return: From: May 23, 2013 To: November 22, 2013 Balance of unallotted securities under 3,446,882scheme(s) from previous return: Plus: The amount by which the block Nilscheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ 19,403allotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 3,427,479yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: May 23, 2013 To: November 22, 2013 Balance of unallotted securities under 210,392scheme(s) from previous return: Plus: The amount by which the block Nilscheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ Nilallotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 210,392yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Portfolio Share Plan Period of return: From: May 23, 2013 To: November 22, 2013 Balance of unallotted securities under 2,400,980scheme(s) from previous return: Plus: The amount by which the block Nilscheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ 168,803allotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 2,232,177yet issued/allotted at end of period: Name of applicant: Shire plc Name of scheme: Employee Stock Purchase Plan Period of return: From: May 23, 2013 To: November 22, 2013 Balance of unallotted securities under 90,000scheme(s) from previous return: Plus: The amount by which the block 1,000,000scheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ 667,699allotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 422,301yet issued/allotted at end of period: Name of contact: Tony Guthrie, Deputy Company Secretary Address of contact: Hampshire International Business Park Basingstoke, Hampshire, RG24 8EP Telephone number of contact: 01256 894746 For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com