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Block Listing Six Monthly Return

23rd Nov 2012 14:45

Block Listing Six Monthly Return

November 23, 2012 - Shire plc

Name of applicant: Shire plc Name of scheme: 2000 Executive Share Option Scheme Period of return: From: May 23, 2012 To: November 22, 2012

Balance of unallotted securities under 3,483,681 scheme(s) from previous return: Plus: The amount by which the block Nil scheme(s) has been increased since the date of the last return (if any increase has been applied for): Less: Number of securities issued/ 7,230 allotted under scheme(s) during period (see LR3.5.7G): Equals: Balance under scheme(s) not 3,476,451 yet issued/allotted at end of period:

Name of applicant: Shire plc Name of scheme: Shire Sharesave Scheme Period of return: From: May 23, 2012 To: November 22, 2012

Balance of unallotted securities under 5,392 scheme(s) from previous return: Plus: The amount by which the block 110,000 scheme(s) has been increased since the date of the last return (if any increase has been applied for): Less: Number of securities issued/ Nil allotted under scheme(s) during period (see LR3.5.7G): Equals: Balance under scheme(s) not 115,392 yet issued/allotted at end of period:

Name of applicant: Shire plc Name of scheme: Portfolio Share Plan Period of return: From: June 8, 2012 To: November 22, 2012

Balance of unallotted securities under Nil scheme(s) from previous return: Plus: The amount by which the block 2,665,000 scheme(s) has been increased since the date of the last return (if any increase has been applied for): Less: Number of securities issued/ 903 allotted under scheme(s) during period (see LR3.5.7G): Equals: Balance under scheme(s) not 2,664,097 yet issued/allotted at end of period:

Name of contact: Tony Guthrie, Deputy Company Secretary Address of contact: Hampshire International Business Park Basingstoke, Hampshire, RG24 8EP

Telephone number of contact: 01256 894746

For further information please contact:

Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

* Behavioral Health and Gastro Intestinal conditions * Rare Diseases * Regenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PXPress Release

www.shire.com

XLON

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Shire
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