Block Listing Six Monthly Return

Block Listing Six Monthly Return December 18, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) Name of applicant: Shire plc Name of scheme: 2.75% Convertible Bonds due 2014 Period of return: From: November 27, To: December 18, 2013 2013 Balance of unallotted securities under Nilscheme(s) from previous return: Plus: The amount by which the block 33,068,902scheme(s) has been increased since thedate of the last return (if anyincrease has been applied for): Less: Number of securities issued/ 33,039,624allotted under scheme(s) during period(see LR3.5.7G): Equals: Balance under scheme(s) not 29,278yet issued/allotted at end of period: The remaining 29,278 securities relating to the Shire plc 2.75% ConvertibleBonds due 2014 have lapsed and these shares have therefore been cancelled. Name of contact: Tony Guthrie, Deputy Company Secretary Address of contact: Hampshire International Business Park Basingstoke, Hampshire, RG24 8EP Telephone number of contact: 01256 894746 For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com