Block Listing Application

Block Listing Application March 9, 2015 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") herebynotifies the market that an application has been made to the UK ListingAuthority and the London Stock Exchange for a total of 2,000,000 ordinaryshares of 5 pence each (the "Shares") to trade on the London Stock Exchange andto be admitted to the Official List. The Shares are to be reserved under ablock listing pursuant to the Shire Portfolio Share Plan. When issued, the Shares will rank equally with the existing issued ordinaryshares of the Company. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Rare Diseases, Neuroscience,Gastrointestinal and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmics. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com