Block Listing Application

Block Listing Application November 14, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company") herebynotifies the market that an application has been made to the UK ListingAuthority and the London Stock Exchange for a total of 500,000 ordinary sharesof 5 pence each (the "Shares") to trade on the London Stock Exchange and to beadmitted to the Official List. The Shares are to be reserved under a blocklisting pursuant to the Shire Employee Stock Purchase Plan. When issued, the Shares will rank equally with the existing issued ordinaryshares of the Company. Tony GuthrieDeputy Company Secretary For further information please contact: Investor Relations Jeff Poulton [email protected] +1 781 482 0945 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We focus on providing treatments in Neuroscience, Rare Diseases,Gastrointestinal, and Internal Medicine and we are developing treatments forsymptomatic conditions treated by specialist physicians in other targetedtherapeutic areas, such as Ophthalmology. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com