Block Listing Application

BLOCK LISTING APPLICATION

A block listing application has been made for 10,000,000 Ordinary Shares of $0.25 each in AstraZeneca PLC (the "Company") to be admitted to the Official List of the UK Listing Authority and admitted to trading on the London Stock Exchange.

Admission is expected to become effective on 15 March 2013.

The shares will be issued fully paid and will rank pari passu in all respects with the existing ordinary shares of the Company and will be issued pursuant to certain of the Company's employee share plans.

A C N Kemp

Company Secretary

14 March 2013