Block Listing Application

Block Listing Application November 4, 2013 - Shire plc (the "Company") (LSE: SHP, NASDAQ: SHPG) herebynotifies the market that an application has been made to the UK ListingAuthority and the London Stock Exchange for a total of 1,000,000 ordinaryshares of 5p each ("Shares") to be admitted to the Official List. These Sharesare being reserved under a block listing and will be issued pursuant to theShire Employee Stock Purchase Plan. These Shares will rank pari passu in all respects with the existing issuedShares of the Company. For further information please contact: Investor Relations Eric Rojas [email protected] +1 781 482 0999 Sarah Elton-Farr [email protected] +44 1256 894157 NOTES TO EDITORS Shire enables people with life-altering conditions to lead better lives. Our strategy is to focus on developing and marketing innovative specialtymedicines to meet significant unmet patient needs. We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,Internal Medicine and Regenerative Medicine and we are developing treatmentsfor symptomatic conditions treated by specialist physicians in other targetedtherapeutic areas. www.shire.com Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX Press Release www.shire.com