Block Listing Application

Block Listing Application

March 26, 2021

LONDON, Silence Therapeutics plc, AIM:SLN and Nasdaq: SLN ("Silence" or "the Company") a leader in the discovery, development and delivery of novel short interfering ribonucleic acid (siRNA) therapeutics for the treatment of diseases with significant unmet medical need, has today made an application to the London Stock Exchange for a block listing of 3,300,000 ordinary shares of 5 pence each in the Company ("Block Listing Shares") to be admitted to trading on the London Stock Exchange ("Admission").

Admission is expected to become effective on 31 March 2021.

These shares are being reserved under a block listing and will be allotted from time to time pursuant to the Silence Therapeutics plc 2018 Employee Long Term Incentive Plan and will rank pari passu with the existing Ordinary Shares of the Company.

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About Silence Therapeutics

Silence Therapeutics is developing a new generation of medicines by harnessing the body's natural mechanism of RNA interference, or RNAi, to inhibit the expression of specific target genes thought to play a role in the pathology of diseases with significant unmet medical need. Silence's proprietary messenger RNAi GOLD™ platform can be used to create siRNAs that precisely target and silence disease-associated genes in the liver, which represents a substantial opportunity. Silence's wholly owned product candidates include SLN360 designed to address the high and prevalent unmet medical need in reducing cardiovascular risk in people born with high levels of lipoprotein(a) and SLN124 designed to address iron loading anemias. Silence also maintains ongoing research and development collaborations with AstraZeneca, Mallinckrodt Pharmaceuticals, and Takeda, among others. For more information, please visit https://www.silence-therapeutics.com/.