Appointment of Nominated Adviser and Broker

1 February 2012

Instem plc

("Instem", or the "Company")

Appointment of Nominated Adviser and Broker

Instem plc (AIM: INS.L), a leading provider of IT applications to the global early development healthcare market, announces that, as a result of the completion of the transfer of the business of the Corporate Advisory & Broking division of Brewin Dolphin Limited to Nplus1 Brewin LLP ("N+1 Brewin"), with effect from today, N+1 Brewin has been appointed as the Company's Nominated Adviser and Broker.

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About Instem plc

Instem (AIM:INS.L) is a leading supplier of IT solutions to the early development healthcare market. Instem's pre-clinical study management solutions accelerate drug and chemical development by increasing productivity, automating processes and enhancing practices that lead to safer and more effective drugs.

In March 2011 Instem acquired BioWisdom Limited, a leading provider of software solutions for extracting intelligence from R&D related healthcare data. The acquisition broadened and strengthened Instem's Centrus™ product suite, accelerating the product development roadmap.

Instem has over 130 customers in North America, Europe, China, India and Japan, including sixteen of the top twenty pharmaceutical and biotech companies such as GlaxoSmithKline and AstraZeneca. The Company employs over 110 people in six offices in the U.S, UK, and China; with additional resource locations in India and a full service distributor in Japan. It is estimated that approximately half of the world's pre-clinical drug safety data has been collected over the last 20 years via Instem software.

To learn more about Instem please visit the Company's website, www.instem.com, or its investor centrehttp://investors.instem.com/.