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Annual Information Update

15th May 2007 15:00

Skyepharma PLC15 May 2007 For Immediate Release 15 MAY 2007 SkyePharma PLC - Annual Information Update In accordance with the requirements of Prospectus Rule 5.2, the followingsummarises the information and documents published, or made available to thepublic, by the Company between 3 May 2006 and 14 May 2007 inclusive. Theinformation referred to in this update was up to date at the time it waspublished but some information may now be out of date. 1. Announcements via RNS The following UK regulatory announcements have been made via RNS a RegulatoryInformation Service and can be obtained from the London Stock Exchange websiteat www.londonstockexchange.com or the Company's website at www.skyepharma.com Date Announcement3 May 2006 Share Purchase Plan8 May 2006 Flutiform Deal8 May 2006 Conference Call Details17 May 2006 Board Appointment19 May 2006 Director Declaration22 May 2006 First Horizon Deal31 May 2006 Asco Presentation31 May 2006 Share Purchase Plan12 Jun 2006 Re Convertible Bonds15 Jun 2006 Notification of Shares21 Jun 2006 Business Review28 Jun 2006 AGM Statement30 Jun 2006 Re: DepoBupivacaine Rights4 Jul 2006 Share Purchase Plan10 Jul 2006 Notification of Shares28 Jul 2006 NASDAQ for Compliance1 Aug 2006 FDA Filing1 Aug 2006 Share Purchase Plan4 Aug 2006 Notification of Shares8 Aug 2006 Adviser Update11 Aug 2006 Re: Share Price Movement21 Aug 2006 Appointment of Auditor31 Aug 2006 Share Purchase Plan5 Sep 2006 Notice of Results6 Sep 2006 European Flutiform Deal22 Sep 2006 Personnel Changes28 Sep 2006 Interim Results4 Oct 2006 Positive Data & EU Filing4 Oct 2006 Director Shareholding9 Oct 2006 Company Secretary Appointment20 Oct 2006 Notification of Interest24 Oct 2006 NDA for Zileuton CR25 Oct 2006 Notification of Shares27 Oct 2006 Notification of Shares31 Oct 2006 Conference Presentation2 Nov 2006 Share Purchase Plan7 Nov 2006 Positive Flutiform Update14 Nov 2006 Board Appointment20 Nov 2006 Presentation at Conference22 Nov 2006 Notification of Interests24 Nov 2006 Notification of Interests27 Nov 2006 Notification of Shares28 Nov 2006 Solaraze Approval30 Nov 2006 Share Purchase Plan18 Dec 2006 FDA Approves Certihaler18 Dec 2006 Transparency Directive19 Dec 2006 Major Interest in Shares27 Dec 2006 GBP35million Fundraising28 Dec 2006 Notification of Shares3 Jan 2007 Share Purchase Plan4 Jan 2007 Notification of Shares9 Jan 2007 Injectable Sale & Placing9 Jan 2007 UK Release Important Details16 Jan 2007 Circular Posting22 Jan 2007 Notification of Shares29 Jan 2007 Notification of Interests1 Feb 2007 Share Purchase Plan8 Feb 2007 EGM Statement14 Feb 2007 Presentation at Conference20 Feb 2007 Notification of Shares1 Mar 2007 Share Purchase Plan9 Mar 2007 Presentation at Conference12 Mar 2007 Holding(s) in Company13 Mar 2007 Holding(s) in Company15 Mar 2007 Agreement for Zileuton CR26 Mar 2007 Completion of Disposal26 Mar 2007 Total Voting Rights2 Apr 2007 Interest in Shares2 Apr 2007 Interest in Shares3 Apr 2007 Annual Information Update3 Apr 2007 Interest in Shares3 Apr 2007 Director Shareholding13 Apr 2007 Regulatory Application17 Apr 2007 Holding(s) in Company18 Apr 2007 EGM Circular18 Apr 2007 Circ re. Incentive Plan23 Apr 2007 Regulatory Approval26 Apr 2007 Final Results1 May 2007 Re: UBS Conference1 May 2007 Further re Final Results3 May 2007 Director/PDMR Shareholding4 May 2007 Delist from NASDAQ4 May 2007 EGM Result4 May 2007 Director Shareholding14 May 2007 Research Update 2. Documents filed at Companies House All of the documents listed below were filed with the Registrar of Companies inEngland and Wales on or around the dates indicated. Copies of the documentsfiled with the Registrar of Companies can be obtained from Companies House(www.companieshouse.gov.uk) Date of Filing Brief Description of document(s) filed07/06/2006 288a Director appointed27/06/2006 288a Director appointed11/07/2006 288b Director resigned11/07/2006 288b Director resigned11/07/2006 288b Director resigned11/07/2006 Res09 Resolutions07/08/2006 AA Annual Accounts16/08/2006 AUD Auditor's resignation06/10/2006 288a Secretary appointed11/10/2006 288b Secretary resigned29/11/2006 288a Director appointed29/11/2006 288b Director resigned09/01/2007 395 Particulars of Mortgage/Charge09/01/2007 395 Particulars of Mortgage/Charge11/01/2007 395 Particulars of Mortgage/Charge12/02/2007 363 Return made up to 31/12/0615/02/2007 395 Particulars of Mortgage/Charge20/03/2007 RES10 Resolutions 3. Documents published or sent to Shareholders or filed with the UK ListingAuthority viewing facility at: Financial Services AuthorityThe North ColonnadeCanary WharfLondonE14 5HS Date Document1 Jun 2006 Annual Report and Notice of Meeting12 Oct 2006 Interim Report15 Jan 2007 EGM Circular and Notice of Meeting18 Apr 2007 EGM Circular and Notice of Meeting Copies of the above documents can be obtained from the Company Secretary at: 105 PiccadillyLondonW1J 7NJ Name of contact and telephone number for queries: John MurphyCompany SecretarySkyePharma PLCTel: 020 7491 1777 This information is provided by RNS The company news service from the London Stock Exchange

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