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Annual Information Update

20th Jun 2007 15:21

20 June 2007

In accordance with the requirements of Prospectus Rule 5.2.1R please find below the Annual Information Update for Shire plc (the "Company"). This is in relation to information that has been published or made available to the public between 21 June 2006 and 19 June 2007.

This Annual Information Update is also being made available on the Investors section of the Company's website, www.shire.com.

The information referred to in this Annual Information Update was correct at the time the information was published, but some information may now be out of date. The information appears by way of record and the Company is under no obligation to update it.

1. Announcements made via a RIS

The documents listed below were published via a Regulatory Information Service on or around the dates indicated.

21/06/2006 Results of the Annual General Meeting 26/06/2006 Barclays PLC and their holding in Shire Goldman Sachs and their holding in Shire 04/07/2006 Holding(s) in Company 07/07/2006 Second Quarter 2006 Results Date Notification Correction : Second Quarter 2006 Results 28 July 2006 21/07/2006 SHIRE ANNOUNCES FILING OF SPD465 24/07/2006 Barclays PLC and their holding in Shire Shire's ELAPRASE (TM) Approved by the FDA 27/07/2006 Kate Nealon appointed Non Executive Director at Shire 28/07/2006 Goldman Sachs and their holding in Shire Second quarter 2006 results 15/08/2006 Shire and Barr Settle All Pending Litigation 16/08/2006 Purchase of Shares by Employee Benefit Trust 17/08/2006 Purchase of Shares by Employee Benefit Trust Fidelity and their holding in Shire Goldman Sachs and their holding in Shire Barclays PLC and their holding in Shire Purchase of Shares by Employee Benefit Trust 18/08/2006 Goldman Sachs and their holding in Shire Purchase of Shares by Employee Benefit Trust Director/PDMR Shareholding 21/08/2006 Director/PDMR Shareholding 22/08/2006 Purchase of Shares by Employee Benefit Trust Barclays PLC and their holding in Shire Director/PDMR Shareholding Purchase of Shares by Employee Benefit Trust 23/08/2006 Franklin Resources and their holding in Shire Purchase of Shares by Employee Benefit Trust 24/08/2006 Jefferies International and their holding in Shire Shire Announces NDA Submission Guanfacine for ADHD Purchase of Shares by Employee Benefit Trust 25/08/2006 Director/PDMR Shareholding 29/08/2006 Purchase of Shares by Employee Benefit Trust Fidelity and their holding in Shire Purchase of Shares by Employee Benefit Trust 30/08/2006 Purchase of Shares by Employee Benefit Trust 31/08/2006 Barclays PLC and their holding in Shire Purchase of Shares by Employee Benefit Trust 01/09/2006 Purchase of Shares by Employee Benefit Trust 04/09/2006 Purchase of Shares by Employee Benefit Trust 05/09/2006 Purchase of Shares by Employee Benefit Trust 06/09/2006 Purchase of Shares by Employee Benefit Trust 07/09/2006 Purchase of Shares by Employee Benefit Trust 08/09/2006 Shire Provides Update on MESAVANCE (TM) Purchase of Shares by Employee Benefit Trust 11/09/2006 Purchase of Shares by Employee Benefit Trust 12/09/2006 Goldman Sachs and their holding in Shire Purchase of Shares by Employee Benefit Trust 13/09/2006 Director/PDMR Shareholding Purchase of Shares by Employee Benefit Trust 14/09/2006 Holding(s) in Company 15/09/2006 Purchase of Shares by Employee Benefit Trust Purchase of Shares by Employee Benefit Trust 18/09/2006 IFRS Information - First half of 2006 Purchase of Shares by Employee Benefit Trust 19/09/2006 Purchase of Shares by Employee Benefit Trust 20/09/2006 Purchase of Shares by Employee Benefit Trust 21/09/2006 Purchase of Shares by Employee Benefit Trust 22/09/2006 Purchase of Shares by Employee Benefit Trust 25/09/2006 Purchase of Shares by Employee Benefit Trust 27/09/2006 Purchase of Shares by Employee Benefit Trust Fidelity and their holding in Shire Purchase of Shares by Employee Benefit Trust 28/09/2006 Director/PDMR Shareholding Purchase of Shares by Employee Benefit Trust 29/09/2006 Purchase of Shares by Employee Benefit Trust Purchase of Shares by Employee Benefit Trust 02/10/2006 Director/PDMR Shareholding 03/10/2006 Director/PDMR Shareholding Shire in-licenses development rights ADDERALL XR Paragraph IV notice received Holding(s) in Company 04/10/2006 Purchase of shares by employee benefit trust 06/10/2006 Purchase of Shares by Employee Benefit Trust 09/10/2006 Regulatory Approval 10/10/2006 Fidelity and their holding in Shire 11/10/2006 Fidelity and their holding in Shire 12/10/2006 Holding(s) in Company 13/10/2006 Q3 2006 RESULTS DATE NOTIFICATION - Oct 27, 2006 Holding(s) in Company 18/10/2006 Purchase of Shares by Employee Benefit Trust 19/10/2006 ELAPRASE (TM) receives positive opinion in Europe 24/10/2006 Goldman Sachs Group and its holdings in Shire 27/10/2006 Excellent Q3 - upgrading 2006 revenue guidance 30/10/2006 Purchase of Shares by Employee Benefit Trust 07/11/2006 Interim IFRS Report filed with the UK Listing Authority 08/11/2006 Purchase of Shares by Employee Benefit Trust Purchase of Shares by Employee Benefit Trust 10/11/2006 Shire sues Andrx Pharmaceuticals, L.L.C. 15/11/2006 Purchase of Shares by Employee Benefit Trust 16/11/2006 Holding(s) in Company 21/11/2006 Director/PDMR Shareholding Director/PDMR Shareholding 27/11/2006 Blocklisting - Interim Review 01/12/2006 Director/PDMR Shareholding 12/12/2006 Dr Jeffrey Leiden appointed Non Executive Director Director Declaration 14/12/2006 Shire receives label agreement in EU for Mezavant(TM) 15/12/2006 Total Voting Rights 18/12/2006 Holding(s) in Company 19/12/2006 Holding(s) in Company 22/12/2006 New River and Shire Receive Approvable Ltr for VYVANSE 11/01/2007 ELAPRASE approved by the European Commission 12/01/2007 Holding(s) in Company 17/01/2007 FDA Approves LIALDA first once-daily mesalamine for UC 18/01/2007 Total Voting Rights 23/01/2007 Shire licenses the North American rights for SPD754 25/01/2007 Holding(s) in Company 12/02/2007 Director/PDMR Shareholding 14/02/2007 Notice of Results Notice of Results 15/02/2007 Total Voting Rights 20/02/2007 Shire Acquires New River Equity financing Final Results RESULT OF EQUITY PLACING 22/02/2007 Director/PDMR Shareholding 23/02/2007 Director/PDMR Shareholding Employee Benefit Trust accouncement 26/02/2007 FDA Approval of prodrug VYVANSE for treatment of ADHD 27/02/2007 Director/PDMR Shareholding 28/02/2007 Director/PDMR Shareholding Holding(s) in Company Holding(s) in Company Holding(s) in Company Holding(s) in Company Holding(s) in Company 01/03/2007 Purchase of Shares by Employee Benefit Trust 02/03/2007 Holding(s) in Company Purchase of Shares by Employee Benefit Trust 06/03/2007 Purchase of Shares by Employee Benefit Trust Purchase of Shares by Employee Benefit Trust 08/03/2007 Purchase of Shares by Employee Benefit Trust 09/03/2007 Purchase of Shares by Employee Benefit Trust Purchase of Shares by Employee Benefit Trust 13/03/2007 Purchase of Shares by Employee Benefit Trust Purchase of Shares by Employee Benefit Trust 14/03/2007 Purchase of Shares by Employee Benefit Trust 16/03/2007 Purchase of Shares by Employee Benefit Trust Purchase of Shares by Employee Benefit Trust 19/03/2007 LIALDA with MMX Technology for UC now Available Merger Update Correction to Purchase of Shares by EBT 20/03/2007 Retirement of David Pendergast at the end of 2007 21/03/2007 Shire files lawsuit 22/03/2007 Holding(s) in Company Holding(s) in Company Director/PDMR Shareholding Purchase of Shares by Employee Benefit Trust 23/03/2007 IFRS results for the year ending December 31, 2006 Director/PDMR Shareholding 26/03/2007 Purchase of Shares by Employee Benefit Trust Notice of EGM 27/03/2007 Purchase of Shares by Employee Benefit Trust 28/03/2007 Purchase of Shares by Employee Benefit Trust Holding(s) in Company 29/03/2007 Purchase of Shares by Employee Benefit Trust 30/03/2007 Purchase of Shares by Employee Benefit Trust 02/04/2007 Director/PDMR Shareholding Total Voting Rights Shire Executive Annual Incentive Plan 03/04/2007 Purchase of Shares by Employee Benefit Trust Additional Listing 04/04/2007 Shire Executive Annual Incentive Plan Director/PDMR Shareholding Director/PDMR Shareholding 05/04/2007 Purchase of Shares by Employee Benefit Trust Movement of shares out of the Employee Benefit Trust 10/04/2007 Purchase of Shares by Employee Benefit Trust 16/04/2007 Results of EGM held on 16 April 2007 Holding(s) in Company 17/04/2007 Notice of Results - First Quarter 2007 Notice of Results - First Quarter 2007 18/04/2007 Tender Offer for New River Shares Successfully completed 20/04/2007 Shire Completes Acquisition of New River 25/04/2007 1st Quarter Results 01/05/2007 Total Voting Rights 02/05/2007 Shire plc announces refinancing of bank facilities Pricing of US$1,000 million Convertible Bonds due 2014 03/05/2007 VYVANSE(TM) Receives Final DEA Schedule Classification Publication of Offering Circular 08/05/2007 Shire announces the Exercise of Over-Allotment Option 11/05/2007 Retirement of Non-Executive Director 18/05/2007 Director/PDMR Shareholding 21/05/2007 FDA Issues Approvable Letter for SPD465 22/05/2007 Director/PDMR Shareholding 29/05/2007 Blocklisting - Interim Review 01/06/2007 Total Voting Rights 19/06/2007 Holding(s) in Company

2. Documents filed at Companies House

All documents listed below were filed with the Registrar of Companies in England and Wales on or around the dates indicated, and can be obtained from Companies House via their website www.companieshouse.gov.uk.

Date Document 30/06/2006 Form 88(2)R - Return of an Allotment of Shares 30/06/2006 Form 88(2)R - Return of an Allotment of Shares 30/06/2006 Form 88(2)R - Return of an Allotment of Shares 30/06/2006 Form 88(2)R - Return of an Allotment of Shares 07/07/2006 Form 88(2)R - Return of an Allotment of Shares 07/07/2006 Form 88(2)R - Return of an Allotment of Shares 11/07/2006 Form 88(2)R - Return of an Allotment of Shares 14/07/2006 Form 88(2)R - Return of an Allotment of Shares 17/07/2006 Form 88(2)R - Return of an Allotment of Shares 18/07/2006 Form 88(2)R - Return of an Allotment of Shares 18/07/2006 Form 88(2)R - Return of an Allotment of Shares 18/07/2006 Form 88(2)R - Return of an Allotment of Shares 18/07/2006 Form 363s - Annual Return 19/07/2006 Form 88(2)R - Return of an Allotment of Shares 20/07/2006 Form 88(2)R - Return of an Allotment of Shares 24/07/2006 Form 88(2)R - Return of an Allotment of Shares 25/07/2006 Form 88(2)R - Return of an Allotment of Shares 27/07/2006 Form 88(2)R - Return of an Allotment of Shares 27/07/2006 Form 88(2)R - Return of an Allotment of Shares 27/07/2006 Form 288a - Appointment of a Director 28/07/2006 Form 88(2)R - Return of an Allotment of Shares 01/08/2006 Form 88(2)R - Return of an Allotment of Shares 02/08/2006 Form 88(2)R - Return of an Allotment of Shares 03/08/2006 Form 88(2)R - Return of an Allotment of Shares 07/08/2006 Form 88(2)R - Return of an Allotment of Shares 07/08/2006 Form 88(2)R - Return of an Allotment of Shares 09/08/2006 Form 88(2)R - Return of an Allotment of Shares 10/08/2006 Form 88(2)R - Return of an Allotment of Shares 11/08/2006 Form 88(2)R - Return of an Allotment of Shares 14/08/2006 Form 88(2)R - Return of an Allotment of Shares 14/08/2006 Form 88(2)R - Return of an Allotment of Shares 15/08/2006 Form 88(2)R - Return of an Allotment of Shares 16/08/2006 Form 88(2)R - Return of an Allotment of Shares 17/08/2006 Form 88(2)R - Return of an Allotment of Shares 18/08/2006 Form 88(2)R - Return of an Allotment of Shares 21/08/2006 Form 88(2)R - Return of an Allotment of Shares 22/08/2006 Form 88(2)R - Return of an Allotment of Shares 24/08/2006 Form 88(2)R - Return of an Allotment of Shares 25/08/2006 Form 88(2)R - Return of an Allotment of Shares 25/08/2006 Form 88(2)R - Return of an Allotment of Shares 29/08/2006 Form 88(2)R - Return of an Allotment of Shares 29/08/2006 Form 88(2)R - Return of an Allotment of Shares 31/08/2006 Form 88(2)R - Return of an Allotment of Shares 01/09/2006 Form 88(2)R - Return of an Allotment of Shares 04/09/2006 Form 88(2)R - Return of an Allotment of Shares 05/09/2006 Form 88(2)R - Return of an Allotment of Shares 05/09/2006 Form 88(2)R - Return of an Allotment of Shares 06/09/2006 Form 88(2)R - Return of an Allotment of Shares 11/09/2006 Form 88(2)R - Return of an Allotment of Shares 11/09/2006 Form 88(2)R - Return of an Allotment of Shares 13/09/2006 Form 88(2)R - Return of an Allotment of Shares 13/09/2006 Form 88(2)R - Return of an Allotment of Shares 04/10/2006 Form 88(2)R - Return of an Allotment of Shares 04/10/2006 Form 88(2)R - Return of an Allotment of Shares 04/10/2006 Form 88(2)R - Return of an Allotment of Shares 04/10/2006 Form 88(2)R - Return of an Allotment of Shares 09/10/2006 Form 88(2)R - Return of an Allotment of Shares 09/10/2006 Form 88(2)R - Return of an Allotment of Shares 09/10/2006 Form 88(2)R - Return of an Allotment of Shares 09/10/2006 Form 88(2)R - Return of an Allotment of Shares 13/10/2006 Form 88(2)R - Return of an Allotment of Shares 13/10/2006 Form 88(2)R - Return of an Allotment of Shares 13/10/2006 Form 88(2)R - Return of an Allotment of Shares 13/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 16/10/2006 Form 88(2)R - Return of an Allotment of Shares 18/10/2006 Form 88(2)R - Return of an Allotment of Shares 19/10/2006 Form 88(2)R - Return of an Allotment of Shares 20/10/2006 Form 88(2)R - Return of an Allotment of Shares 23/10/2006 Form 88(2)R - Return of an Allotment of Shares 23/10/2006 Form 88(2)R - Return of an Allotment of Shares 24/10/2006 Form 88(2)R - Return of an Allotment of Shares 25/10/2006 Form 88(2)R - Return of an Allotment of Shares 26/10/2006 Form 88(2)R - Return of an Allotment of Shares 30/10/2006 Form 88(2)R - Return of an Allotment of Shares 31/10/2006 Form 88(2)R - Return of an Allotment of Shares 02/11/2006 Form 88(2)R - Return of an Allotment of Shares 06/11/2006 Form 88(2)R - Return of an Allotment of Shares 06/11/2006 Form 88(2)R - Return of an Allotment of Shares 08/11/2006 Form 88(2)R - Return of an Allotment of Shares 09/11/2006 Form 88(2)R - Return of an Allotment of Shares 10/11/2006 Form 88(2)R - Return of an Allotment of Shares 13/11/2006 Form 88(2)R - Return of an Allotment of Shares 14/11/2006 Form 88(2)R - Return of an Allotment of Shares 15/11/2006 Form 88(2)R - Return of an Allotment of Shares 17/11/2006 Form 88(2)R - Return of an Allotment of Shares 17/11/2006 Form 88(2)R - Return of an Allotment of Shares 24/11/2006 Form 88(2)R - Return of an Allotment of Shares 24/11/2006 Form 88(2)R - Return of an Allotment of Shares 24/11/2006 Form 88(2)R - Return of an Allotment of Shares 24/11/2006 Form 88(2)R - Return of an Allotment of Shares 24/11/2006 Form 88(2)R - Return of an Allotment of Shares 24/11/2006 Form 88(2)R - Return of an Allotment of Shares 24/11/2006 Form 88(2)R - Return of an Allotment of Shares 27/11/2006 Form 88(2)R - Return of an Allotment of Shares 27/11/2006 Form 122 28/11/2006 Form 88(2)R - Return of an Allotment of Shares 28/11/2006 Form 88(2)R - Return of an Allotment of Shares 29/11/2006 Form 88(2)R - Return of an Allotment of Shares 29/11/2006 Form 88(2)R - Return of an Allotment of Shares 30/11/2006 Form 88(2)R - Return of an Allotment of Shares 30/11/2006 Form 88(2)R - Return of an Allotment of Shares 04/12/2006 Form 88(2)R - Return of an Allotment of Shares 04/12/2006 Form 88(2)R - Return of an Allotment of Shares 04/12/2006 Form 88(2)R - Return of an Allotment of Shares 04/12/2006 Form 88(2)R - Return of an Allotment of Shares 04/12/2006 Form 88(2)R - Return of an Allotment of Shares 05/12/2006 Form 88(2)R - Return of an Allotment of Shares 06/12/2006 Form 88(2)R - Return of an Allotment of Shares 06/12/2006 Form 88(2)R - Return of an Allotment of Shares 07/12/2006 Form 88(2)R - Return of an Allotment of Shares 07/12/2006 Form 88(2)R - Return of an Allotment of Shares 07/12/2006 Form 88(2)R - Return of an Allotment of Shares 08/12/2006 Form 88(2)R - Return of an Allotment of Shares 08/12/2006 Form 88(2)R - Return of an Allotment of Shares 08/12/2006 Form 88(2)R - Return of an Allotment of Shares 11/12/2006 Form 88(2)R - Return of an Allotment of Shares 11/12/2006 Form 88(2)R - Return of an Allotment of Shares 12/12/2006 Form 88(2)R - Return of an Allotment of Shares 13/12/2006 Form 88(2)R - Return of an Allotment of Shares 14/12/2006 Form 88(2)R - Return of an Allotment of Shares 15/12/2006 Form 88(2)R - Return of an Allotment of Shares 15/12/2006 Form 88(2)R - Return of an Allotment of Shares 15/12/2006 Form 88(2)R - Return of an Allotment of Shares 19/12/2006 Form 88(2)R - Return of an Allotment of Shares 19/12/2006 Form 88(2)R - Return of an Allotment of Shares 20/12/2006 Form 88(2)R - Return of an Allotment of Shares 20/12/2006 Form 88(2)R - Return of an Allotment of Shares 21/12/2006 Form 88(2)R - Return of an Allotment of Shares 21/12/2006 Form 88(2)R - Return of an Allotment of Shares 02/01/2007 Form 88(2)R - Return of an Allotment of Shares 02/01/2007 Form 88(2)R - Return of an Allotment of Shares 02/01/2007 Form 88(2)R - Return of an Allotment of Shares 02/01/2007 Form 88(2)R - Return of an Allotment of Shares 02/01/2007 Form 288a - Appointment of a Director 03/01/2007 Form 88(2)R - Return of an Allotment of Shares 03/01/2007 Form 88(2)R - Return of an Allotment of Shares 03/01/2007 Form 88(2)R - Return of an Allotment of Shares 10/01/2007 Form 88(2)R - Return of an Allotment of Shares 10/01/2007 Form 88(2)R - Return of an Allotment of Shares 10/01/2007 Form 88(2)R - Return of an Allotment of Shares 11/01/2007 Form 88(2)R - Return of an Allotment of Shares 12/01/2007 Form 88(2)R - Return of an Allotment of Shares 15/01/2007 Form 88(2)R - Return of an Allotment of Shares 16/01/2007 Form 88(2)R - Return of an Allotment of Shares 16/01/2007 Form 88(2)R - Return of an Allotment of Shares 17/01/2007 Form 88(2)R - Return of an Allotment of Shares 17/01/2007 Form 88(2)R - Return of an Allotment of Shares 17/01/2007 Form 88(2)R - Return of an Allotment of Shares 19/01/2007 Form 88(2)R - Return of an Allotment of Shares 19/01/2007 Form 88(2)R - Return of an Allotment of Shares 19/01/2007 Form 88(2)R - Return of an Allotment of Shares 19/01/2007 Form 288b - Resignation of a Director 23/01/2007 Form 88(2)R - Return of an Allotment of Shares 23/01/2007 Form 88(2)R - Return of an Allotment of Shares 24/01/2007 Form 88(2)R - Return of an Allotment of Shares 24/01/2007 Form 88(2)R - Return of an Allotment of Shares 26/01/2007 Form 88(2)R - Return of an Allotment of Shares 26/01/2007 Form 88(2)R - Return of an Allotment of Shares 26/01/2007 Form 88(2)R - Return of an Allotment of Shares 29/01/2007 Form 88(2)R - Return of an Allotment of Shares 29/01/2007 Form 88(2)R - Return of an Allotment of Shares 30/01/2007 Form 88(2)R - Return of an Allotment of Shares 01/02/2007 Form 88(2)R - Return of an Allotment of Shares 01/02/2007 Form 88(2)R - Return of an Allotment of Shares 01/02/2007 Form 88(2)R - Return of an Allotment of Shares 06/02/2007 Form 88(2)R - Return of an Allotment of Shares 06/02/2007 Form 88(2)R - Return of an Allotment of Shares 06/02/2007 Form 88(2)R - Return of an Allotment of Shares 09/02/2007 Form 88(2)R - Return of an Allotment of Shares 09/02/2007 Form 88(2)R - Return of an Allotment of Shares 14/02/2007 Form 88(2)R - Return of an Allotment of Shares 14/02/2007 Form 88(2)R - Return of an Allotment of Shares 14/02/2007 Form 88(2)R - Return of an Allotment of Shares 16/02/2007 Form 88(2)R - Return of an Allotment of Shares 16/02/2007 Form 88(2)R - Return of an Allotment of Shares 16/02/2007 Form 88(2)R - Return of an Allotment of Shares 21/02/2007 Form 88(2)R - Return of an Allotment of Shares 21/02/2007 Form 88(2)R - Return of an Allotment of Shares 21/02/2007 Form 88(2)R - Return of an Allotment of Shares 26/02/2007 Form 88(2)R - Return of an Allotment of Shares 27/02/2007 Form 88(2)R - Return of an Allotment of Shares 28/02/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 14/03/2007 Form 88(2)R - Return of an Allotment of Shares 23/03/2007 Form 88(2)R - Return of an Allotment of Shares 23/03/2007 Form 88(2)R - Return of an Allotment of Shares 23/03/2007 Form 88(2)R - Return of an Allotment of Shares 23/03/2007 Form 88(2)R - Return of an Allotment of Shares 27/03/2007 Form 88(2)R - Return of an Allotment of Shares 27/03/2007 Form 88(2)R - Return of an Allotment of Shares 27/03/2007 Form 88(2)R - Return of an Allotment of Shares 04/04/2007 Form 88(2)R - Return of an Allotment of Shares 04/04/2007 Form 88(2)R - Return of an Allotment of Shares 04/04/2007 Form 88(2)R - Return of an Allotment of Shares 04/04/2007 Form 88(2)R - Return of an Allotment of Shares 04/04/2007 Form 88(2)R - Return of an Allotment of Shares 16/04/2007 Form 88(2)R - Return of an Allotment of Shares 16/04/2007 Form 88(2)R - Return of an Allotment of Shares 16/04/2007 Form 88(2)R - Return of an Allotment of Shares 16/04/2007 Form 88(2)R - Return of an Allotment of Shares 16/04/2007 Form 88(2)R - Return of an Allotment of Shares 16/04/2007 Form 88(2)R - Return of an Allotment of Shares 18/04/2007 Form 88(2)R - Return of an Allotment of Shares 18/04/2007 Form 88(2)R - Return of an Allotment of Shares 18/04/2007 Form 88(2)R - Return of an Allotment of Shares 23/04/2007 Form 88(2)R - Return of an Allotment of Shares 23/04/2007 Form 88(2)R - Return of an Allotment of Shares 23/04/2007 Form 88(2)R - Return of an Allotment of Shares 23/04/2007 Form 88(2)R - Return of an Allotment of Shares 27/04/2007 Form 88(2)R - Return of an Allotment of Shares 27/04/2007 Form 88(2)R - Return of an Allotment of Shares 27/04/2007 Form 88(2)R - Return of an Allotment of Shares 02/05/2007 Form 88(2)R - Return of an Allotment of Shares 02/05/2007 Form 88(2)R - Return of an Allotment of Shares 02/05/2007 Form 88(2)R - Return of an Allotment of Shares 02/05/2007 Form 88(2)R - Return of an Allotment of Shares 02/05/2007 Form 88(2)R - Return of an Allotment of Shares 04/05/2007 Form 88(2)R - Return of an Allotment of Shares 10/05/2007 Form 88(2)R - Return of an Allotment of Shares 10/05/2007 Form 88(2)R - Return of an Allotment of Shares 10/05/2007 Form 88(2)R - Return of an Allotment of Shares 10/05/2007 Form 88(2)R - Return of an Allotment of Shares 10/05/2007 Form 88(2)R - Return of an Allotment of Shares 10/05/2007 Form 288b - Resignation of a Director 16/05/2007 Form 88(2)R - Return of an Allotment of Shares 16/05/2007 Form 88(2)R - Return of an Allotment of Shares 16/05/2007 Form 88(2)R - Return of an Allotment of Shares 24/05/2007 Form 88(2)R - Return of an Allotment of Shares 24/05/2007 Form 88(2)R - Return of an Allotment of Shares 24/05/2007 Form 88(2)R - Return of an Allotment of Shares 24/05/2007 Form 88(2)R - Return of an Allotment of Shares 24/05/2007 Form 88(2)R - Return of an Allotment of Shares 24/05/2007 Form 88(2)R - Return of an Allotment of Shares 24/05/2007 Form 88(2)R - Return of an Allotment of Shares 30/05/2007 Form 88(2)R - Return of an Allotment of Shares 30/05/2007 Form 88(2)R - Return of an Allotment of Shares 30/05/2007 Form 88(2)R - Return of an Allotment of Shares 30/05/2007 Form 88(2)R - Return of an Allotment of Shares 06/06/2007 Form 88(2)R - Return of an Allotment of Shares 06/06/2007 Form 88(2)R - Return of an Allotment of Shares 06/06/2007 Form 88(2)R - Return of an Allotment of Shares 06/06/2007 Form 88(2)R - Return of an Allotment of Shares 12/06/2007 Form 88(2)R - Return of an Allotment of Shares 12/06/2007 Form 88(2)R - Return of an Allotment of Shares 12/06/2007 Form 88(2)R - Return of an Allotment of Shares 12/06/2007 Form 88(2)R - Return of an Allotment of Shares 12/06/2007 Form 88(2)R - Return of an Allotment of Shares

3. Documents filed with the Securities and Exchange Commission ("SEC")

The Company submitted filings to the SEC in compliance with its obligations under national laws and rules dealing with the regulation of securities, issuers of securities and securities markets by virtue of having American Depository shares admitted to trading on the NASDAQ. Full details of these filings can be found on the SEC's website at www.sec.gov.

4. Documents sent to Shareholders

The following documents were published and sent to shareholders. They are available on the Company's website.

Date Document

26/03/2007 Notice of Extraordinary General Meeting

21/05/2007 Annual Report and Accounts

21/05/2007 Notice of Annual General Meeting

A copy of this Annual Information Update and copies of the documents referred to in it can be obtained from the Deputy Company Secretary at the Company's registered office.

T MayCompany Secretary

For further information please contact:

Investor Relations Clƒ©a Rosenfeld (Rest of the World) +44 1256 894 160 Eric Rojas (North America) +1 484 595 8252 Notes to editorsSHIRE PLC

Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire believes that a carefully selected portfolio of products with a strategically aligned and relatively small-scale sales force will deliver strong results.

Shire's focused strategy is to develop and market products for specialty physicians. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe.

For further information on Shire, please visit the Company's website: www.shire.com.

Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com Press Release

Registered in England 5492592Registered Office as above

SHIRE PLC

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