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Skyepharma PLC03 April 2007 3 APRIL 2007 SkyePharma PLC - Annual Information Update In accordance with the requirements of Prospectus Rule 5.2, the followingsummarises the information and documents published, or made available to thepublic, by SkyePharma between 2 May 2005 and 2 May 2006 The informationreferred to in this update was up to date at the time it was published but someinformation may now be out of date. SkyePharma also confirms that it will issue a further Annual Information Update,within the 20 business days following publication of its annual results, whichwill cover the 12-month period immediately preceding such announcement. 1. Announcements via RNS The following UK regulatory announcements have been made via RNS a RegulatoryInformation Service and can be obtained from the London Stock Exchange websiteat www.londonstockexchange.com or the Company's website at www.skyepharma.com Date Announcement 6 May 2005 Additional Listing9 May 2005 Triglide Approval23 May 2005 Notification of Shares24 May 2005 Notification of Shares31 May 2005 Signed Agreement1 Jun 2005 Share Purchase Plan2 Jun 2005 Directors Share Purchase3 Jun 2005 Director Shareholding3 Jun 2005 Director Shareholding6 Jun 2005 Re Convertible Bonds20 Jun 2005 Approval in Germany21 Jun 2005 Notification of Shares28 Jun 2005 Paxil CRTM Returns to US28 Jun 2005 First Filing for Pulmicort1 Jul 2005 Share Purchase Plan18 Jul 2005 US Launch of Triglide18 Jul 2005 AGM Statement20 Jul 2005 Notification of Shares2 Aug 2005 Share Purchase Plan3 Aug 2005 Notification of Shares3 Aug 2005 2004 IFRS Figures31 Aug 2005 Notification of Shares2 Sep 2005 Results Date & Flutiform Update7 Sep 2005 Launch of Foradil8 Sep 2005 Notice of Interims28 Sep 2005 Rights Issue28 Sep 2005 Interim Results30 Sep 2005 Notification of Interests30 Sep 2005 Notification of Shares3 Oct 2005 Director/PDMR Shareholding3 Oct 2005 Holding(s) in Company5 Oct 2005 Notification of Shares5 Oct 2005 R&D Day Update6 Oct 2005 Notification of Shares6 Oct 2005 Notification of Shares12 Oct 2005 Filing of Prospectus17 Oct 2005 Notification of Shares18 Oct 2005 Notification of Shares18 Oct 2005 Notification of Shares - Amend19 Oct 2005 Notification of Shares21 Oct 2005 Notification of Shares24 Oct 2005 Notification of Shares25 Oct 2005 Notification of Shares1 Nov 2005 Japanese Marketing Agreement1 Nov 2005 Notification of Shares3 Nov 2005 Rights Issue3 Nov 2005 Placement of Rights Issue Rump3 Nov 2005 Director/PDMR Shareholding7 Nov 2005 Notification of Shares10 Nov 2005 Notification of Shares14 Nov 2005 Strategic Review14 Nov 2005 Rule 2.10 Announcement17 Nov 2005 Rule 2.10 Announcement18 Nov 2005 Rule 2.10 Announcement30 Nov 2005 Notification of Shares2 Dec 2005 Holding(s) in Company2 Dec 2005 Notice of Major Interests5 Dec 2005 Notification of Shares8 Dec 2005 Strategic Review Update13 Dec 2005 Notification of Shares28 Dec 2005 Share Purchase Plan11 Jan 2006 Strategic Review12 Jan 2006 Postponement of R&D Days13 Jan 2006 Notice of Major Interest16 Jan 2006 Notice of Major Interest20 Jan 2006 Resignation of Chairman20 Jan 2006 Responds to Call for EGM23 Jan 2006 Holding(s) in Company26 Jan 2006 Holding(s) in Company30 Jan 2006 Further re call for EGM2 Feb 2006 Appointment of New Chairman3 Feb 2006 Director/PDMR Shareholding3 Feb 2006 Director/PDMR Shareholding3 Feb 2006 Director Shareholding3 Feb 2006 Notification of Shares6 Feb 2006 Board Appointment6 Feb 2006 Notification of Shares6 Feb 2006 Notification of Shares7 Feb 2006 Response to NAV Syndicate7 Feb 2006 Notification of Shares8 Feb 2006 Notification of Shares9 Feb 2006 Further re Employment Terms9 Feb 2006 Notification of Shares9 Feb 2006 Notification of Shares13 Feb 2006 Former Chairman Retires13 Feb 2006 Notification of Shares13 Feb 2006 Notification of Shares14 Feb 2006 Notification of Shares15 Feb 2006 Director/PDMR Shareholding16 Feb 2006 EGM Circular23 Feb 2006 Notification of Shares23 Feb 2006 Notification of Shares27 Feb 2006 EGM Nominee Voting1 Mar 2006 Share Purchase Plan2 Mar 2006 Response to NAV3 Mar 2006 Full Response to NAV3 Mar 2006 Notification of Shares3 Mar 2006 Financial Position6 Mar 2006 Holding(s) in Company9 Mar 2006 Result of EGM14 Mar 2006 Agreement over Non-Executives15 Mar 2006 Notification of Shares17 Mar 2006 Notification of Shares27 Mar 2006 Notice of Results3 Apr 2006 Share Purchase Plan5 Apr 2006 Board Appointment19 Apr 2006 Preliminary Results21 Apr 2006 Propofol Update24 Apr 2006 Holding(s) in Company24 Apr 2006 Notification of Interests24 Apr 2006 Directors Share Awards26 Apr 2006 Notification of Interests28 Apr 2006 European Approval of DepoDur2 May 2006 Notification of Shares 2. Documents filed at Companies House All of the documents listed below were filed with the Registrar of Companies inEngland and Wales on or around the dates indicated. Copies of the documentsfiled with the Registrar of Companies can be obtained from Companies House(www.companieshouse.gov.uk) Date of Filing Brief Description of document(s) filed 16/05/2005 88(2)R Return Allotment of Shares28/07/2005 AA Annual Accounts30/07/2005 RES09 Resolutions03/08/2005 288b Director Resigned27/09/2005 288c Directors Particulars Changed30/01/2006 363 Return made up to 31/12/0522/02/2006 288b Director resigned 3. Documents published or sent to Shareholders or filed with the UK ListingAuthority viewing facility at: Financial Services Authority The North Colonnade Canary Wharf London E14 5HS Date Document June 2005 Annual Report and Notice of MeetingOctober 2005 Interim ReportOctober 2005 Rights Issue ProspectusFebruary 2006 EGM Circular and Notice of Meeting Copies of the above documents can be obtained from the Company Secretary at: 105 Piccadilly London W1J 7NJ Name of contact and telephone number for queries: John Murphy Company Secretary SkyePharma PLC Tel: 020 7491 1777 This information is provided by RNS The company news service from the London Stock ExchangeRelated Shares:
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