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Annual Information Update

2nd Jun 2010 07:00

2 June 2010 Source BioScience plc (`Source BioScience', or `the Company') Annual Information Update

For the purposes of complying with its obligations under Prospectus Rule 5.2.1, Source BioScience announces that the information below has been published or made available to the public over the previous 12 months in accordance with laws and rules dealing with regulation of securities, issues of securities and securities markets.

Details of all regulatory announcements for the Company can be found on the London Stock Exchange website at www.londonstockexchange.com or on the Source BioScience website www.sourcebioscience.com.

1. Announcements made via the Regulatory Information Service ("RNS")

The announcements listed below were published by the Company via RNS on thedates indicated: 19/05/2009 Annual Information Update 04/06/2009 AGM Statement 04/06/2009 Result of AGM 15/06/2009 Director/PDMR Shareholding 15/06/2009 Director/PDMR Shareholding 15/06/2009 Director/PDMR Shareholding 23/07/2009 Extended Agreement with Cervical Screening Wales 12/08/2009 Notice of Results 24/08/2009 Appointment of Joint Stockbroker 25/08/2009 Half-yearly Report 17/11/2009 Interim Management Statement 26/11/2009 Company to offer Fluidigm SNP genotyping service (RNS Reach) 26/01/2010 Expansion of DNA sequencing capacity 15/02/2010 Change of Advisor 23/02/2010 Opening of Dublin DNA sequencing facility 04/03/2010 Notice of Results 09/03/2010 Company orders UK's first Illumina HiSeq 2000 (RNS Reach) 24/03/2010 Final Results 30/03/2010 Holding(s) in Company 31/03/2010 AstraZeneca Service Agreement (RNS Reach) 19/04/2010 Holding(s) in Company 14/05/2010 Notice of AGM 17/05/2010 Companion diagnostic testing for stomach cancer (RNS Reach) 18/05/2010 Interim Management Statement

2. Documents filed at Companies House

The Company has submitted the following documents at Companies House on thedates indicated: 09/06/2009 Annual Accounts 06/10/2009 SAIL address created 06/10/2009 Register moved to SAIL address 27/10/2009 Director's change of particulars 28/01/2010 Annual Return 02/02/2010 Declaration of satisfaction in full or in part of a mortgage or charge 02/02/2010 Declaration of satisfaction in full or in part of a mortgage or charge 02/02/2010 Declaration of satisfaction in full or in part of a mortgage or charge 02/02/2010 Declaration of satisfaction in full or in part of a mortgage or charge 02/02/2010 Declaration of satisfaction in full or in part of a mortgage or charge

3. Documents sent to shareholders

The Company has dispatched the following documents to holders of its securities during the last 12 months on the dates indicated:

25/08/2009 Half-yearly report 14/05/2010 Annual Report and Accounts, including Notice of AGM

A copy of this Annual Information Update (which also appears on the Company website www.sourcebioscience.com) and all the documents referred to in it, can be obtained from the Company's registered office, Source BioScience plc, 1 Orchard Place, Nottingham Business Park, Nottingham, NG8 6PX.

This annual information update is required by and is being made pursuant to Article 10 of the Prospectus Directive as implemented in the United Kingdom (Prospectus Rule 5.2) and not for any other purpose and neither the Company, nor any other person, takes any responsibility for, or makes any representation, express or implied, as to the accuracy or completeness of, the information which it contains. This information is not necessarily up to date as at the date of this annual information update and the Company does not undertake any obligation to update any such information in the future. Furthermore, such information may have been prepared in accordance with the laws or regulations of a particular jurisdiction and may not comply with or meet the relevant standards of disclosure in any other jurisdiction. This annual information update does not constitute an offer of any securities addressed to any person and should not be relied upon by any person.

For further information, please contact:

Source BioScience plcDr Nick AshManaging Director+ 44 (0) 115 973 [email protected]

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