Admission to Trading and First Day of Dealings

27 March 2026

Coiled Therapeutics plc

("Coiled Therapeutics" or the "Company")

Admission to Trading and First Day of Dealings

Clinical stage oncology company joins AIM

Coiled Therapeutics plc (AIM:COIL), previously called Roquefort Therapeutics plc, is pleased to announce, in conjunction and simultaneously with the completion of the acquisition of the exclusive worldwide licence to AO-252, the admission of its ordinary shares to trading on the AIM Market of the London Stock Exchange today at 8:00am ("Admission") under the ticker "COIL" and an ISIN GB00BSHRN331.

Admission follows the successful Fundraise of £8.5 million (before expenses) at 10 pence per New Ordinary Share through the issue of 85,000,000 New Ordinary Share with institutional investors.

More information on Coiled Therapeutics and a copy of the Admission Document can be found here: www.coiledplc.com.

Highlights

· Successful transition from a pre-clinical platform to a material clinical-stage oncology company focused on precision medicine.

· Lead asset AO-252 is a first-in-class, orally administered, brain-penetrant small molecule inhibitor targeting TACC3, a validated previously undruggable oncology target.

· Early Phase I data in advanced solid tumours is encouraging, having already demonstrated tumour reductions of up to 33% in endometrial and 29% in ovarian cancer patients at sub-therapeutic exposure levels.

· AO-252 has shown a favourable benign safety and tolerability profile to date, contrasting positively with traditional forms of cancer treatment.

· Entry into the high value precision oncology market where comparable approved therapies currently command a market size exceeding US$20 billion.

· Completion of the £8.5 million (gross) Fundraise provides the capital runway to reach key clinical and value inflection points relating to the development of AO-252 in 2026 and 2027.

· Strong backing from A2A Pharmaceuticals, Inc. ("A2A Pharma") and its investor group, who have a proven track record of billion-dollar value creation in the biotech sector.

· Expansion of the AO-252 Phase I trial into prostate and ovarian cancers is underway, with material data readouts anticipated by Q4 2026 providing near term catalysts to support commercial discussions.

· Potential to advance directly from Phase I to registration grade Phase II trial, expediting the route to market authorisation.

· In addition to AO-252, the Company is assessing its STAT-6 siRNA programme for a Phase I clinical trials for immunology, providing a potential dual asset pipeline.

· The Board and management team has deep expertise in drug discovery, regulatory strategy, successful clinical and commercial execution.

Dr Sotirios Stergiopoulos, Executive Chairman of Coiled Therapeutics, commented:

"We are delighted to have completed the transaction and to begin Coiled Therapeutics' journey as an AIM quoted company. AO-252 is a first-in-class asset that is already delivering encouraging signals of efficacy in patients with advanced solid tumours who have exhausted all other treatment options.

The Fundraise will allow us to drive forward our dual indication strategy, which prioritises the expansion of our Phase I trial into patients with prostate and ovarian cancers. These are areas where patients face a major lack of effective therapies after failing standard treatments. We believe AO-252's unique ability to target TACC3 and cross the blood-brain barrier offers a potential lifeline for these patients.

With the support of our new and existing shareholders, we have the necessary capital to accelerate these programmes and generate the material data readouts required to drive forward partnering discussions. By addressing these critical unmet medical needs, we are focused on reaching the key clinical inflection points that will drive our commercial strategy and create significant long-term value for our shareholders."

Note

Capitalised terms which are not defined in this announcement have the same meaning given to them in the Admission Document which was published on 2 March 2026.

Enquiries:

About Coiled Therapeutics plc

Coiled Therapeutics (AIM: COIL) is an AIM-listed, clinical-stage biotechnology company focused on developing innovative precision oncology therapies. Its lead programme, AO-252, is a novel TACC3 inhibitor currently in Phase I clinical trials in the USA (trials ID: NCT06136884). Coiled Therapeutics is actively enrolling patients to test for safety and efficacy in patients whose cancer has progressed on other treatments. The Company is also assessing its STAT-6 siRNA programme for immunology indications. Coiled Therapeutics is supported by a leadership team with a proven track record in drug development and strategic backing from A2A Pharmaceuticals.

About AO-252

AO-252 is a first-in-class, orally administered, brain-penetrant small molecule inhibitor of Transforming Acidic Coiled-Coil containing protein 3 (TACC3). TACC3 is a validated oncology target that is frequently overexpressed in many aggressive, hard-to-treat solid tumours but is dispensable in normal adult cells, providing a wide therapeutic window.

By selectively disrupting cancer-critical protein-protein interactions at the TACC3 C-terminal domain, AO-252 induces mitotic and replication stress, impairs DNA damage repair, and triggers cancer cell death. Notably, AO-252 has demonstrated the ability to cross the blood-brain barrier, addressing a significant unmet medical need for the treatment of brain metastases.

The asset is currently in an ongoing Phase I open-label dose-escalation study and early clinical signals have shown encouraging anti-tumour activity and a benign safety profile, with the Company planning to initiate dose expansion cohorts in lead indications, including prostate and ovarian cancer, during 2026.

For more information, please visit: www.coiledplc.com

Board of Coiled Therapeutics plc

Dr. Sotirios Stergiopoulos, Executive Chairman

Dr. Stergiopoulos is a distinguished physician executive with extensive global experience in the pharmaceutical and biotechnology industries, specifically within oncology. He previously served as the Chief Medical Officer of Ipsen, a multi-billion-dollar Euronext-listed pharmaceutical company. His clinical background includes roles as an Attending Physician and trainee at prestigious institutions, including the Albert Einstein College of Medicine, Harvard Medical School, and the National Institutes of Health (NIH). He holds a Medical Degree from Poznan University of Medical Sciences and a Master's in Biotechnology Enterprise and Entrepreneurship (MBEE) from Johns Hopkins University.

Sridhar Vempati, Chief Executive Officer

Mr. Vempati brings nearly 20 years of expertise in drug discovery, oncology research, and business strategy. He has a proven track record of advancing novel therapeutics from initial concept through to clinical development. In 2016, he co-founded A2A Pharma, where he served as Chief Strategy Officer and oversaw the computational drug design platforms that discovered AO-252. His earlier career includes roles in business development at Ironwood Pharmaceuticals and Rafael Pharmaceuticals, as well as experience as an Equity Research analyst at Jefferies LLC. He holds a PhD in molecular biology from Ludwig-Maximilians-University, Germany, and an MBA from Boston University.

Jean Marie Duvall, Non-Executive Director

Ms. Duvall is a highly accomplished leader in the biopharma sector with over 25 years of experience. She was a key executive board member at Ferring Pharmaceuticals during its growth from $700 million to $2 billion in revenue. Her expertise spans corporate development, M&A, and legal affairs, having previously served as General Counsel at Elan Corporation. She has co-founded several biotech start-ups, including Trizell and Amzell, which have successfully moved products through Phase II and Phase III clinical trials. She is currently the CEO of ReproNovo SA.

Pamela Frank, Non-Executive Director

Ms. Frank is an expert in strategic coalition building and regulatory advocacy with over 30 years of experience. She currently serves as Senior VP at Gabel Associates and CEO of ChargEVC, a non-profit focused on sustainable energy. She has a strong background in public health and policy development, having served on various advisory councils for the Governor of New Jersey. She holds a Master of Public Health (MPH) from the University of Medicine & Dentistry of New Jersey and brings a wealth of experience in navigating complex multi-stakeholder environments and governance.

Stephen West, Non-Executive Director

Mr. West is a Fellow Chartered Accountant with over 30 years of experience in international financial, corporate, and public company management. He was a co-founder of Roquefort Therapeutics plc and has held senior executive and board positions across several sectors, including life sciences and natural resources. Notably, he was instrumental in the $100 million merger of African Petroleum Corporation and PetroNor E&P.