Acquisition

NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART IN, IN OR INTO OR FROM ANY JURISDICTION WHERE TO DO THE SAME WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OF SUCH JURISDICTION

London, 27 January 2011

BTG PLC ("BTG")

Acquisition of Biocompatibles International plc ("Biocompatibles")

Offer Update: Scheme Effective

BTG, the specialist pharmaceuticals company, is pleased to announce that the Court Orders have today been delivered to the Registrar of Companies and the Scheme has therefore become effective.

Biocompatibles has made an application to the London Stock Exchange for the cancellation of the admission to trading of Biocompatibles Shares on its main market for listed securities and to the UK Listing Authority for the cancellation of the admission of the Biocompatibles Shares to the Official List, in each case to be effective from 8:00 a.m. (London time) tomorrow, 28 January 2011.

BTG will make applications to the London Stock Exchange and the UK Listing Authority in respect of the Admission of the New BTG Shares from 8.00 a.m. (London time) tomorrow, 28 January 2011.

Terms defined in the Scheme Document shall have the same meaning(s) when used in this announcement.

A copy of this announcement will be available on the Company's website at www.btgplc.com by no later than 12:00 noon (London time) on 28 January 2011 (subject to certain restrictions relating to persons resident in restricted jurisdictions).

For further information contact:

BTG

Louise Makin, Chief Executive Officer

+44 (0) 20 7575 0000

Andy Burrows, Director of Investor Relations+44 (0)20 7575 1741+44 (0)7990 530605 (mobile)

Rolf Soderstrom, Chief Financial Officer+44 (0)20 7575 0000

Financial DynamicsBen Atwell+44 (0)20 7831 3113

Rothschild (financial adviser and joint sponsor to BTG)

Dominic Hollamby

+44 (0)20 7280 5000

Julian Hudson

+44 (0)20 7280 5000

J.P. Morgan Cazenove (joint sponsor and corporate broker to BTG)

James Mitford

+44 (0)20 7742 4000

Gina Gibson

+44 (0)20 7742 4000