26th Feb 2025 09:27
(Alliance News) - AstraZeneca PLC on Wednesday said its drug camizestrant significantly delayed disease progression in a phase III trial for advanced hormone receptor-positive breast cancer, supporting its potential as a new treatment option.
The Cambridge, England-based pharmaceuticals firm said the Serena-6 trial showed that switching to camizestrant in combination with a cyclin-dependent kinase 4/6 inhibitor after the emergence of an ESR1 mutation led to a statistically significant and clinically meaningful improvement in progression-free survival, compared with continuing treatment with an aromatase inhibitor and a CDK4/6 inhibitor.
The company said the study is the first to use a circulating tumour DNA-guided approach to detect endocrine resistance early and adjust treatment before disease progression. Key secondary endpoints, including time-to-second disease progression and overall survival, remain under evaluation.
AstraZeneca said camizestrant worked with all widely approved CDK4/6 inhibitors—palbociclib, ribociclib, and abemaciclib—while maintaining a safety profile consistent with existing treatments.
The company plans to present full results at an upcoming medical meeting and share findings with regulatory authorities.
Shares in AstraZeneca were up 1.2% at 12,080.00 pence in London on Wednesday morning.
By Eva Castanedo, Alliance News reporter
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