14th Jul 2025 08:50
(Alliance News) - AstraZeneca PLC on Monday said a test of its baxdrostat drug showed a "meaningful reduction" in hypertension.
The Cambridge, England-based pharmaceutical and biotechnology firm reported that some primary endpoints and all secondary endpoints were met in a third-phase trial of baxdrostat.
Testing measured systolic blood pressure, or SBP, in patients with "uncontrolled or treatment resistant hypertension", who were administered one of two different baxdrostat doses, or a placebo. AstraZeneca said the drug showed a "statistically significant" reduction in mean seated SBP.
AstraZeneca shares were up 2.2% to 10,681.21 pence in London after the Monday morning announcement.
Baxdrostat is a selective inhibitor of aldosterone, the hormone that may be responsible for higher SBP, according to some researchers. The drug is under investigation for potential use as a monotherapy for hypertension, and as a possible kidney disease treatment in combination with dapagliflozin. AstraZeneca also hopes the drug will help prevent heart failure, given that high SBP is a "leading risk factor for cardiovascular disease", noted the trial's primary investigator, Bryan Williams.
Commented Sharon Barr, AstraZenca's executive vice president of Biopharmaceuticals Research & Development: "These findings provide compelling evidence of baxdrostat's potential to address a critical unmet need by targeting aldosterone dysregulation, bringing a novel mechanism to a field that has seen little innovation in over two decades."
By Holly Munks, Alliance News reporter
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