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\* TFORM 8.3DEALINGS BY PERSONS WITH INTERESTS IN SECURITIES REPRESENTING 1% OR MORE(Rule 8.3 of the Takeover Code) 1. KEY INFORMATION Name of person dealing (Note 1) Loeb Holding Corporation Company dealt in Premier Research Group Plc Class of relevant security to whichthe dealings being disclosed relate (Note 2) Ordinary Date of dealing April 29, 2008 2. INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE(a) Interests and short positions (following dealing) in the class of relevant security dealt in (Note 3) Long Short Number (%) Number (%)(1) Relevant securities(2) Derivatives (other than options) 1,800,000 2.99%(3) Options and agreements to purchase/sellTotal 1,800,000 2.99%(b) Interests and short positions in relevant securities of the company, other than the class dealt in(Note 3)Class of relevant security: Long Short Number (%) Number (%)(1) Relevant securities(2) Derivatives (other than options)(3) Options and agreements to purchase/sellTotal(c) Rights to subscribe (Note 3)Class of relevant security: Details 3. DEALINGS (Note 4) (a) Purchases and sales Purchase/sale Number of securities Price per unit (Note 5) (b) Derivatives transactions (other than options) Product name, e.g. CFD Long/short (Note 6) Number of securities (Note 7) Price per unit (Note 5)SWAP Long 350,000 96.75 GBp (c) Options transactions in respect of existing securities (i) Writing, selling, purchasing or varyingProduct name, Writing, selling, Number of securities Exercise Type, e.g. Expiry Option moneye.g. call option purchasing, varying etc. to which the option price American date paid/received relates (Note 7) European etc. per unit (Note 5)(ii) ExercisingProduct name, e.g. call option Number of securities Exercise price per unit (Note 5) (d) Other dealings (including new securities) (Note 4) Nature of transaction (Note 8)Details Price per unit (if applicable) (Note 5) 4. OTHER INFORMATIONAgreements, arrangements or understandings relating to options or derivatives Full details of any agreement, arrangementor understanding between the person disclosing and any other person relating to the voting rights of any relevantsecurities under any option referred to on this form or relating to the voting rights or future acquisition or disposalof any relevant securities to which any derivative referred to on this form is referenced. If none, this should bestated. Is a Supplemental Form 8 attached? (Note 9) NODate of disclosure April 30, 2008Contact name Shelby DrescherTelephone number 212-483-7070If a connected EFM, name of offeree/offeror with which connectedIf a connected EFM, state nature of connection (Note 10) NotesThe Notes on Form 8.3 can be viewed on the Takeover Panel's website at www.thetakeoverpanel.org.uk\* T Copyright Business Wire 2008Related Shares:
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